Research Associate, Library Synthesis

At X-Chem, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health.  X-Chem is a leader in small molecule discovery science, providing pharmaceutical and biotechnology companies a complete, seamless solution for screening, hit validation, and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, the company leverages its market-leading DEL platform to rapidly screen billions of diverse drug-like molecules to discover novel small molecule leads against challenging, high-value therapeutic targets. In house hit-to-lead and lead optimization services driven by AI and physics-based modeling enable clients to progress their compounds directly from hit all the way through to candidate nomination. Our well-proven expertise in medicinal chemistry, custom synthesis, and scale-up process chemistry enables us to support all aspects of drug discovery in a deeply integrated technology-driven platform. 

Job Responsibilities

• • High-throughput, on-DNA reaction validation
  • Reaction optimization of on-DNA chemistry
  • Library synthesis for DNA-encoded-libraries (DELs)
  • Buffer preparations
  • Reagent and comsumables ordering
  • Document and communicate experimental results clearly, both within the team and in cross-site meetings
  • Ensure high-quality experimental execution, meticulous record keeping, and adherence to laboratory safety standards
  • Collaborate closely with the DEL team and global colleagues to align priorities and advance ongoing projects
  • Contribute to continuous improvement of internal methods, protocols, and workflows

Essential Qualifications

• Requirements for the position include a BS or MS in Chemistry or related subject
• 6 months to 2 years of laboratory experience in an industrial or academic setting
• Experience in organic synthesis in an industrial or academic setting
• Needs to be well organized and detail oriented
• Needs to be able to multitask and set prioritizations to meet timelines
• Needs to have excellent communication skills
• Needs to be meticulous with their documentation and data handling
• Needs to be able to work in a team environment

Preferred Qualifications

• Working familiarity with LCMS is highly valuable
• The ability to present scientific data internally/externally

Why Join Us

X-Chem offers competitive compensation and benefits programs designed to meet the diverse needs of our global colleagues. Our Pay for Performance philosophy and practices reward colleagues based on the contributions they make to our business.

Our competitive benefits programs support our colleagues by:

Promoting health and wellness to help colleagues maintain and improve their physical and mental wellbeing. X-Chem offerings include private health insurance, preventative health programs, and personal wellness benefits.

Offering flexible and meaningful benefits, including flexible working hours, long-term loyalty rewards, language learning opportunities, and access to experiences that encourage relaxation, recreation, and cultural enrichment.

How to Apply

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