Research Scientist, DMPK

X-Chem, Inc. is the leader in small molecule discovery science, providing pharmaceutical and biotech companies a complete, seamless solution for screening, hit validation and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, the company leverages its market-leading DEL platform to discover novel small molecule leads against challenging, high-value therapeutic targets. X-Chem empowers partners to rapidly screen billions of diverse, drug-like compounds simultaneously and easily identify potent hits that exhibit desired selectivity and mode of action with attractive physicochemical properties. In-house lead optimization services enable clients to progress their compounds directly for even higher quality outputs. Our expertise in medicinal chemistry, custom synthesis and scale-up process chemistry enables us to support all aspects of drug discovery, supporting lead optimization through candidate identification. Our research scientists were responsible for over 100 patents, 17 compounds advanced to IND-enabling toxicology studies, and 7 compounds reaching Phase I or beyond.

X-Chem is seeking a motivated Research Scientist in DMPK to join the Discovery Chemistry Team in Montreal and reporting to the Executive Director, Medicinal Chemistry, to help drive our drug discovery research programs. Key responsibilities of the successful candidate include the following:

• Participate in the development of Standard Operating Procedures (SOPs) for DMPK
• Develop and validate a range of in vitro ADME and Physicochemical Chemistry (LogD) assays
• Design and execute studies to understand the ADME properties of drug candidates
• Participate in the ordering and the inventory management of the research chemicals including biologicals required to support in vitro DMPK assays

Qualifications

• M.Sc. and/or Ph.D. in Pharmaceutical sciences, Chemistry, Biology or related disciplines with knowledge of DMPK
• Minimum 1–3 years’ experience in performing and interpreting in vitro DMPK studies in the biotech/pharmaceutical industry or CRO sector
• Knowledge performing LogD, plasma protein binding, CYP450 inhibition 
• Proficient in operating and troubleshooting HPLC-tandem mass spectrometers (LC-MS/MS)
• Outstanding written and verbal communication skills
• Hepatocyte stability and/or drug permeability (Caco-2 or MDCKII) assays is desirable but not mandatory
• Current work authorization in Canada

The company cooperates with its customers, mainly in the United States, and with partners and colleagues outside Quebec for the research and development of medical products based on the identification and optimization of small molecules enabling the development of specific drugs. Interaction with colleagues and partners outside Quebec, notably in Budapest and Waltham, is constant. Consequently, knowledge of English is required for this unique and specialized position.  

Knowledge of French is required for positions permanently located in Quebec, so that the incumbent can communicate as needed with colleagues, customers and partners in Quebec.

Our research scientists innovate beyond reported chemistry while focusing on delivery. We all share a passion for staying at the forefront of medicinal and synthetic chemistry. To drive innovation, we acknowledge the importance of intelligent risk-taking, open-mindedness and initiative. We encourage creativity in an informal environment and recognize everyone’s contribution as part of a team to work together toward a common vision.

What are the benefits joining us?

We are focused on the development and career progression of our people to reach their full potential through workshops, training courses and mentor guidance. X-Chem offers competitive compensation (salary and performance incentive) and interesting benefits package. Benefits we offer include: Medical, Dental, STD/LTD and Life Insurance, Retirement Plan with employer match; paid vacations starting at 3 weeks plus paid Christmas shutdown; casual dress, vision care including prescription safety glasses, training sessions and workshops, social hours and team-building company events.