Senior Computational Chemist

Location:  Remote in the US or Canada; candidates based in proximity to our medicinal chemistry center-of-excellence in Montreal will be of particular interest 

The Opportunity:   X-Chem, Inc. is a leader in small molecule discovery science, providing pharmaceutical and biotechnology companies a complete, seamless solution for screening, hit validation, and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, the company leverages its market-leading DEL platform to rapidly screen billions of diverse drug-like molecules to discover novel small molecule leads against challenging, high-value therapeutic targets.  In house lead optimization services driven by AI and physics-based modeling enable clients to progress their compounds directly in-house from hit all the way through to candidate nomination.  Our well-proven expertise in medicinal chemistry, customer synthesis, and scale-up process chemistry enables us to support all aspects of drug discovery in a deeply integrated technology-driven platform.

What you’ll do:  X-Chem is seeking a highly motivated and experienced Senior Computational Chemists to establish a strong in-house computational capability to support our excellence in innovative drug discovery services. The ideal candidate will play a pivotal role in advancing our clients' drug discovery efforts by leading computational modeling usage, developing workflows that combine virtual and real-world approaches, and integrating with our proprietary machine learning platform, ArtemisAI. 

• Collaborate closely with interdisciplinary experimental, scientific, and technology development teams in developing/deploying new technology, integrations and supporting rapid evolution of a global chemistry platform.  
• Utilize structure-based, ligand-based, and machine learning/generative AI design help lead client discovery projects.  
• Drive the development of new computational tools, informatics-based pipelines, and integrated workflows to support our client’s drug discovery projects. 
• Contribute to infrastructure improvements, software portfolio recommendations, and prospecting of relevant cutting-edge computational technologies/companies. 

What you’ll need: 

• Ph.D. in Computational Chemistry, Medicinal Chemistry, or related field + 2yrs experience beyond a postdoc or a BS/MS in the above with 6 years experience in the drug discovery industry. 
• Experience leading drug discovery projects from a computational perspective. 
• A solid understanding of the drug discovery process 
• Proficiency in structure-based design, ligand-based design, and cheminformatics tools, including open-source and commercial. 
• Experience with machine learning/AI methodologies for drug discovery is desirable. 
• Familiarity with scripting languages is a strong plus (eg Python, bash) 
• Demonstrated ability to work effectively in a collaborative, fast-paced environment with excellent problem-solving skills and flexibility to adapt to new challenges and changes in direction.  
• Strong communication skills and experience in working with global teams and customers 

Why you should join us:

X-Chem offers highly competitive compensation based on prior experience and qualifications as well as comprehensive benefits in order to best support our people.  Benefits we offer include Medical, Dental, Disability, and Life Insurance; Paid Holidays and Time Off; Tuition Reimbursement and Professional Development; social hours and company events. Our work environment includes casual dress, bike storage, free parking, and wellness perks.

EEO Statement:

X-Chem is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.